With appropriate controls, replication, and sample sizes. Experiments must have been conducted rigorously, The manuscript must describe a technically sound piece of scientific research withĭata that supports the conclusions. Is the manuscript technically sound, and do the data support the conclusions? Please respond to the reviewer comments below.ġ. The PLOS ONE style templates can be found at Please ensure that your manuscript meets PLOS ONE's style requirements, including When submitting your revision, we need you to address these additional requirements.ġ. We look forward to receiving your revised manuscript. Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab ProtocolĪrticles, which describe protocols hosted on protocols.io. Its own identifier (DOI) so that it can be cited independently in the future. To enhance the reproducibility of your results. If applicable, we recommend that you deposit your laboratory protocols in protocols.io Guidelines for resubmitting your figure filesĪre available below the reviewer comments at the end of this letter. If you would like to make changes to your financial disclosure, please include your This as a separate file labeled 'Manuscript'. An unmarked version of your revised paper without tracked changes.You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'. A marked-up copy of your manuscript that highlights changes made to the original version.You should upload this letter as a separate file labeled 'Response to Reviewers'. A rebuttal letter that responds to each point raised by the academic editor and reviewer(s).Please include the following items when submitting your revised manuscript: The journal office at When you're ready to submit your revision, log on to and select the 'Submissions Needing Revision' folder to locate your manuscript file. Time than this to complete your revisions, please reply to this message or contact Please submit your revised manuscript by 11:59PM. Manuscript that addresses the points raised during the review process. Therefore, we invite you to submit a revised version of the We feel that it has merit but does not fully meet PLOS ONE’s publication criteriaĪs it currently stands. Thank you for submitting your manuscript to PLOS ONE. Symptoms from 2010 to 2019 in JapanPLOS ONE PONE-D-22-02306Trends in proton pump inhibitor use, reflux esophagitis, and various upper gastrointestinal